• Histologically confirmed stage IV colon cancer (AJCC 7th edition) that has progressed after standard therapy that included 5-FU, irinotecan, oxaliplatin and appropriate antibody therapy. Antibody therapy with bevacizumab and an anti-EGFR antibody, if RAS wild type, should have been given unless medical reasons have precluded their use. Participants who could not tolerate standard agents because of unacceptable, but reversible toxicity necessitating their discontinuation will be allowed to participate.

• Participants who had received adjuvant chemotherapy and had recurrence during or within six months of completion of the adjuvant chemotherapy will be allowed to count the adjuvant therapy as one chemotherapy regimen for advanced disease.

• Progression of disease must be documented on the most recent scan.

• Presence of measurable disease

• RAS mutation and MMR status must be determined (or tissue availability for testing if not already determined).

• Age 18 years or older.

• ECOG performance status 0-1.

• Life expectancy of at least three months.

• Participants with adequate organ function:

‣ Absolute neutrophil count (ANC) \> 1.5 x 109/L

⁃ Hemoglobin \> 9 g/dL

⁃ Platelets (PLT) \> 70 x 109/L

⁃ AST/ALT \< 5 x ULN

⁃ Albumin within normal limits for institution

• Women who are nursing and discontinue nursing prior to enrollment in the program.

• Ability to take oral medication (i.e., no feeding tube).

• Participant able and willing to comply with study procedures as per protocol.

• Participant able to understand and willing to sign and date the written voluntary informed consent form (ICF) at screening visit prior to any protocol-specific procedures.